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Zinc based Indian traditional drug (Yashad Bhasma):Preparation, characterization and its bacterial response

Richa Bhargava, Naresh Kumar, Ranu K.Dutta, Avinash C.Pandey, N.K.Singh, Sanjeev Kumar

We report on the preparation of Zinc based ‘Yashad BhasmaÂ’ that involves purification of pure Zinc metal using herbal juices followed by detoxification and calcinations at high temperature (~ 900°C). The structural, optical and elemental properties of the Yashad Bhasma have been investigated. The structural study of Yashad Bhasma revealed the existence of single phase ZnO with Hexagonal wurzite structure. Fourier transform- infra red (FT-IR), Photoluminescence (PL), Raman Spectroscopy, and Energy dispersive X-Ray analysis (EDX), confirms the presence of only ZnO without any other impurity in these Bhasmas.We also report on the effect ofYashad bhasma on the growth of Escherichia coli (E. Coli) DH5 and Listeria monocytogenes (L. monocytogenes) bacteria. Preliminary results showthat Yashad Bhasma is less toxic as in comparison to the earlier studied ZnO Nanoparticles. Even at very high concentration i.e. 4500 ìg/ml, the inhibitory effect is very mild. In vitro study suggests that the particles ofYashad Bhasma are not toxic to the microorganismpresent in the environment and the growth pattern does not change in the presence of these particles.