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Validated liquid chromatographic method for niacin and simvastatin in pharmaceutical preparation

Pravish Kumar Tiwari, P.A.Sathe


A simple, sensitive and validated HPLC method has been developed to determine niacin and simvastatin simultaneously in pharmaceutical preparation. Chromatographic separation was achieved on a C-8 column using a mixture of phosphate buffer pH 3.0 and methanol in the ratio of 20:80 (v/v) at a wavelength of 237 nm. Linearity of the method was found to be in the concentration range of 75-525g/ml for niacin and 1.5 -10.5g/ml for simvastatinwith correlation coefficient greater than 0.999. The total eluting time for the two components is less than ten minutes. The method can be used for simultaneous determination of niacin and simvastatin.


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