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Urinary lipid quantitation in nephrotic syndrome

Jeevan K.Shetty, Shivananda B.Baliga, Mungli Prakash, K.Gopalakrishna, Sanath Sadananda, B.Shivaraj

Nephrotic syndrome is characterized by proteinuria, lipiduria, hypoalbuminemia, and edema. Studies determining the levels of urinary cholesterol and urinary triglycerides are very few. Studywas carried out in 44 primary (group I), 54 secondary (groupII) cases of nephrotic syndrome and 40 healthy controls for group I cases and 30 for group II cases. Urinary cholesterol, urinary triglycerides, serum albumin, creatinine and fasting lipid profiles were estimated. There was significant increase in urinary cholesterol and urinary triglycerides excretion in group I cases compared to group II (p<0.001). There was significant rise in lipid parameters in cases compared to controls (p<0.05). Correlation was observed between urinary total protein and urinary total cholesterol (r=0.936 p<0.001, r=0.599 p< 0.001), urinary total triglycerides (r=0.456 p<0.001, r =0.440 p<0.001). Negative correlation was observed between serum albumin and urinary total cholesterol in group I cases (r=-0.474 p<0.001). In conclusion we found significantly increased lipiduria in primary nephrotic syndrome compared to secondary nephrotic syndrome.