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Toxicogenomics and PD; Is there a possible role?

Mohamed M.Salama

PD is a neurodegenerative disease with progressive pathology. The role of genetics and environmental exposure has been supported by many researches. One of the problems facing PD treatment is that clinical picture is delayed until severe degeneration occurs in the neurons. A need for early detectors of PD has been increased after the discovery of many candidate neuroprotectant agents where early detection would mean early intervention and a possible better prognosis. Toxicogenomics is a field combining both the toxic exposure with gene expression changes. Such technique would be perfect to conditions like PD where both genetics and toxicology is intermingled. The enthusiasmfor toxicogenomics application in PDshould not prevent further steps to validate this technique before using it in clinical practice.