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Synthesis of some new phenothiazine and pyridine derivatives as antipsychotic and anticonvulsant agents

Ashok Kumar, Hemlata Kaur, Sunil Kumar, K.K.Saxena

A series of 3-[{5-(heterocyclic methyl)-1,3,4-oxadiazol-2-yl}-2- (substitutedphenyl)]thiazolidin-4-ones (5a-5i) and 1-[{5-(heterocyclic methyl) 1,3,4-oxadiazol-2-yl}-3-chloro-4-(substituted phenyl)]azetidin-2-one (6a- 6i) have been synthesized by the reaction of 5-(heterocyclic methyl)-2- (substitutedbenzylidene)-1,3,4-oxadiazol-2-amines (4a-4i)with thioglycolic acid and chloroacetyl chloride respectively.All the newly synthesized compounds (4a-4i), (5a-5i) and (6a-6i) were screened for their antipsychotic and anticonvulsant activities. Structures of all the compounds were established by elemental and spectral (IR, and 1H NMR) analysis.