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Synthesis of Benzoimidazole Selenato Complexes and Determination of its Antitumor Activity

Meenakshi Bhardwaj, Mayank Bansal, Shiv K. Gupta and Amit K. Das

Different selenium complexes were synthesized using benzimidazole selenato ligand of Zn (II), Hg (II), Cd (II), Cu (II) and Ni (II). The derivatives M [Se (BIA)]2 (where M = Zn, Ni, Cu, Cd, Hg and BIA- benzimidazole) were prepared by the reaction of MCl2 with lithium arene selenato ligand of BIASe+Li−. The compounds synthesized were identified and characterized by various methods like melting point, thin layer chromatography, nuclear magnetic resonance, mass spectroscopy, atomic absorption spectroscopy, and screening for anti tumor activity was carried out of all the derivatives using Ehlirch asicites carcinoma (EAC) cells induced in albino mice. Out of the complex synthesized, selenato metallic complexes Zn[Se(BIA)]2 and Ni[Se(BIA)]2 were found to be potent antitumor, since these compounds have shown increase in RBC, decrease in WBC, increase in life span , decrease in ascities fluid volume , increase in lymphocytes significantly.