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Synthesis, characterization, and antibacterial activity of novel amine N-halamine-grafted silica nanoparticles with core-shell structure

Chenghao Li, Alideertu Dong

Novel amine N-halamine-grafted silica nanoparticles with core-shell structure were facilely fabricated by grafting polymeric amine N-halamine on silica nanoparticles for fighting against pathogenic bacteria. The products were characterized by different techniques such as transmission electron microscopy (TEM), scanning electron microscopy (SEM), and the modified iodometric/thiosulfate technique. The antibacterial activity of the products was verified by selecting Gram-positive bacteria S. aureus and Gram-negative bacteria E. coli as models via the plate counting method and zone of inhibition study. The antimicrobial results showed that the products possess powerful bactericidal capability against both model pathogen bacteria. Such an investigation opens up a novel idea of making them the potent candidates for deactivating bacteria or even disease control