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Synthesis and spectral characterization of potential impurities of tiaprofenic acid

Ramadas Chavakula, M.Narayana Rao, K.Praveen Kumar, Ch.Srinivas Rao, B.Gopi Babu,R.V.Nageswara Rao

During the process development of tiaprofenic acid (1). Two impurities A&C with respect to tiaprofenic acid were detected by in-house method of simple reverse phase high-performance liquid chromatography (HPLC). Two impurities A&C have been prepared. The 1H and 13C NMR data of impuritiesA&C were reported in this paper for the first time. Based on the spectral data, the structure of these impuritiesA&C were characterized as (5-Ethylthiophen-2-yl)phenylmethanone and (2RS)-2-(5-benzoylthiophen- 3-yl) propanoic acid. The synthesis, characterization of these impurities were discussed.