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Synthesis and Potential Antibacterial Activity of Hydrazone Derivatives with Imidazo[1,2-a]pyridine support against Escherichia Coli.

Souleymane Coulibaly

This work presents the synthesis and investigated the antibacterial activity of seventeen (17) hydrazone derivatives with imidazo[1,2-a] pyridine support (5a-q). These compounds were obtained by condensation between 2-hydrazino-3-nitroimidazo[1,2-a] pyridine and aldehyde derivatives. The synthesized compounds were characterized by spectroscopic analyses (1H, 13C NMR), and High-Resolution Mass Spectrometry (HRMS). A preliminary antibacterial activity of the 5a-q compounds was determined on an E. coli strain by the disc diffusion method. The results showed that among the 17, 12-imidazo[1,2-a] pyridinehydrazone derivatives were potent with inhibition diameters between 8 mm and 11 mm. Compound 5a was more active with a diameter of 11 mm.