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Synthesis and Pharmacological Evaluation of Some 3-(2-Fluorneyl)-5-(Substituted Phenyl)-4,5-Dihydroisoxazoles

Ganesamoorthy Thirunarayanan

Totally twenty seven 3,5-substituted 4,5-dihydro isoxazole derivatives including 3-(2-fuorneyl)-5-(substituted phenyl)-4,5-dihydroisoxazole have been synthesized by fly-ash:H2SO4 catalyzed intramolecular cycloaddition of hydroxylamine hydrochloride and aryl chalcones under solvent-free conditions. The yields of the isoxazoles are more than 90%. The synthesized isoxazole were characterized by their physical constants and spectral data. The anti-microbial and antioxidant activities of the synthesized isoxazoles have been evaluated using a variety of bacterial and fungal species and DPPH radical scavenging methods.