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Synthesis and Evaluation of Antifungal Activity of Novel Indole Derivatives

S. D. Kulkarni, A. N. Tankar, B. G. Ram, D. B. Ghongade, B. G. Chandak and R. N. Tiwari

Novel Mannich bases of indole were synthesized by using a series of secondary amines and formaldehyde in presence of ethanol with magnetic stirring for 4-6 hours in cold condition. The structures of these compounds were established on the basis of spectral data. The final compounds were screened for antifungal activity against Candida albicans using cup- plate method. Ketoconazole was used as standard drug.