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Synthesis and Evaluation of Amide Prodrugs of Mefenamic Acid

V. S. Tegeli and H. N. More

A series of amide prodrugs of mefenamic acid (a known non-steroidal anti-inflammatory drug) have been synthesized with an aim to obtain new compounds with potential analgesic and anti-inflammatory activity. The structures of all synthesized compounds were confirmed by means of infrared, proton magnetic resonance and mass spectroscopy. All compounds were evaluated for their anti-inflammatory activities by carrageenan-induced rat paw edema test. Most of the synthesized compounds induced significant reduction in the writhing response when compared to control. The anti-inflammatory activity of these compounds were evaluated and showed significant anti-inflammatory activity in comparison to control but their effect was weaker than mefenamic acid.