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Synthesis and Antimicrobial Activity of S-Hepta-O-Benzoyl Lactosyl-1-Aryl-5-Phenyl-2,4-Isodithiobiurets

Reena J. Deshmukh and Shirish P. Deshmukh

Condensation of S-hepta-O-benzoyl lactosyl-1-arylisothiocarbamides and phenyl isothiocyanate resulted in the formation of S-hepta-O-benzoyl lactosyl-1-aryl-5-phenyl-2,4-isodithiobiurets. The required lactosyl arylisothiocarbamides were prepared by the interaction of S-hepta-O-benzoyl lactosyl bromide with aryl thiocarbamides. These newly synthesized compounds were characterized on the basis of chemical transformation, elemental analysis and IR, 1H NMR and Mass spectral studies. The polarimetric study of the titled compounds has been carried out. These compounds were screened for their antibacterial and antifungal activities against various pathogenic bacteria and fungi. The products showed good to moderate activity against above microorganisms.