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Studies on the Development of Transdermal Patches of Nisoldipine

A. Abdul Hasan Sathali and L. Mageshkumar

The transdermal route of administration has been recognized as one of the highly potential routes. Transdermal drug delivery systems deliver the drugs across epidermis to achieve systemic effects and also it control, the delivery of drugs by employing an appropriate polymer. The objective of the present work was to develop a suitable transdermal drug delivery system of nisoldipine. Nisoldipine is a second generation dihydropyridine calcium antagonist and used in the treatment of stable angina and arterial hypertension. Polymeric films of nisoldipine were prepared by the solvent evaporation technique on mercury substrate. The physicochemical compatibility of the drug and the polymers were studied by infrared spectroscopic and differential scanning calorimetric studies. Transdermal patches were prepared with different ratios of combination of polymers like HPMC : EC, PVP : EC, ERL 100 : EC, ERS100 : EC. They were evaluated for physicochemical parameter in vitro release and ex vivo permeation. Release of the drug from the films followed anomalous transport (0.5 < n <1). Polymeric combination containing Eudragit RL 100 : EC in 2 : 3 ratio (ERL100 : EC; 2 : 3) (F 10) was considered as the best formulation with maximum drug release of 71.86% after 12 hrs. The flux of formulation F10 was found to be greater than the other formulations. The histopathological study confirmed that the formulations were free of potential skin toxicity.