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sSynthesis and antibacterial activity of a Mannich base, N1[1-(4-hydroxyphenyl)-1-morpholinopropyl] semicarbazide and its Cu(II) complex

B.M.Dhoot, M.B.Swami

The synthesis of Cu(II) complex derived from Mannich base N1[1-(4- hydroxyphenyl)-1-morpholinopropyl] semicarbazide (HPMPS) derived by the condensation of 4-hydroxy propiophenone, morpholine and semicarbazide. Its structure has been confirmed on the basis of analytical, magnetic and spectral studies. The Cu(II) complex exhibit square-planar geometry. The antibacterial activity of synthesized ligand (HPMPS) and its Cu(II) complex was studied by the usual cup-plate-agar-diffusion method againstGram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The qualitative and quantitative antimicrobial activity test results proved that the Cu(II) complex is very active than the free ligand. The increase in antibacterial activity is due to faster diffusion of metal complex as a whole through the cell membrane or due to the combined activity effect of the metal and ligand.