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Spectroscopic studies and biological evaluation of transition metal complexes of Schiff bases derived from 5-nitro-o-vanilline

K.R.Joshi, J.H.Pandya, A.J.Rojivadiya

Two new series of cobalt(II), nickel(II) and copper(II) complexes with two Schiff base, HL1 and HL2; ligands have been prepared. The Schiff base, HL1 and HL2, ligandswere synthesized by the condensation of 5-nitro-o-vanilline with 5-chloro-o-anisidine and 2,5-dichloroaniline respectively.All compounds were characterized by spectroscopy, elemental and thermal analyses techniques. This azomethine compounds were found to form complexes readily with cobalt(II), nickel(II) and copper(II). FromIRand electronic spectral studies, the phenolic oxygen and imine nitrogen of the ligand were found to be the coordination sites. The structure of the complex obtained was confirmed by FT-IR, electronic spectra, ESI Mass and 1H NMR. The metal complexes exhibit different geometrical arrangements such as square planar, tetrahedral, and distorted octahedral arrangement. These ligands as well as their metal complexes were also evaluated for their antimicrobial activity against several bacterial strains, such as Staphylococcus aureus, Pseudomonas aeruginosa and E. coli. and also such funguses, candida albicans and aspergillus-niger.