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Solvent Impact on Average Roughness and Microstructural Features of Metformin Drug an AFM Investigations

Khaled M. Elsabawy and A. El-Maghraby

These investigations were performed on three different sources of highly pure metformin crystallized and extracted from three different types of solvent namely toluene, methanol and acetone. The roughness of metformin surface’s were monitored by using high resolution AFM-microscope. Results indicated that as roughness of surface increases, dissolution rates increase due to surface area exposure to the solvated molecules are increased; moreover, the estimated grain sizes decreased as detected by AFMinvestigations specially in case of methanol solvent.