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Simultaneous Spectrophotometric Estimation of Cilostazol and Aspirin in Synthetic Mixture

J. V. Patel, C. N. Patel, I. S. Anand, P. U. Patel and P. H. Prajapati

 estimation of aspirin and cilostazol in the synthetic mixture. Aspirin has absorbance maxima at 226 nm and cilostazol has absorbance maxima at 257 nm in methanol. The linearity was observed in the concentration range of 2-24 μg/mL for the both aspirin and cilostazol. First method is based on the simultaneous equations; Absorbances of both the drugs were determined at 226 nm (<max of aspirin) and at 257 nm (max of cilostazol). The method was validated in terms of accuracy (99.30 ± 0.97, 101.58 ± 0.89). Second method is based on Q-absorbance ratio; absorbances of both the drugs were determined at 226 nm (max of aspirin) and at isoabsorptive point (239.5 nm). Q-absorption ratio method was validated in terms of accuracy (98.05 ± 1.20, 99.12 ± 1.00). The proposed methods were found accurate