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Simultaneous determination of anti hypertensive drugs in human plasma

G.Kumar1, T.B.Patrudu, Tentu. Nageswara Rao, N.Krishna Rao, Karri Apparao

A simple, touchy and inexpensive procedure got its start applying solid-phase extraction, combined with high performance liquid chromatographic procedure along with UV detection intended for determination of candesartan cilexetil and azilsartan medoxomil residues in human plasma. The evaluated parameters include the extracts by using silica gel the use of a aggregate of ethyl acetate/ 0.5 % formic acid (1:4, v/v) as eluent. The method was established the usage of plasma samples spikedwith candesartan cilexetil and azilsartan medoxomil at different concentration levels (0.03 and 0.3 mg/L). Average recoveries (using each concentration six replicates) ranged 84-92%, with relative standard deviations less than 2%, calibration solutions concentration in the range 0.03- 10.0mg/L and limit of detection (LOD) and limit of quantification (LOQ)were 0.01 µg/mL and 0.03 mg/L respectively.