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Secondary metabolite steroids isolated from medicinal entomogenous mushroom Cordyceps jiangxiensis mycelium

Jian-Hui Xiao, Zhong-Hua Sun, Wei-Dong Pan, Jian-Jiang Zhong

Cordyceps jiangxiensis, a medicinal entomogenous mushroom, showed potent antitumor activity as described previously. In this present study, four steroids including docosanoic acid campesterol-ester (1), hexadecanoic acid ergosterol-ester (2), ergosterol (3), 5á-Ergosta-7,22-dien-3â-ol (4)were isolated fromchloroformand ethyl acetate fractions ofmethanol extract of Cordyceps jiangxiensis mycelium by bioassay-guided fractionation, respectively. The chemical structures of four compounds were elucidated on the basis of their physical and spectroscopic properties. Among these compounds, compounds 1 and 2 were two new ergosteryl esters of longchain alkanes, and compound 4 was obtained from the genus Cordyceps for the first time.