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RP-HPLC Method for the Estimation of Famciclovir in Bulk and Pharmaceutical Dosage Form

Syed Nizamuddin, K. C. Prashanth, T. Shekshavali, B. K. Sridhar and S. Appala Raju

A rapid and reproducible RP-HPLC chromatographic method has been developed for the estimation of famciclovir in its pure form as well as in pharmaceutical formulation. Chromatography was carried out on an C18 column using a mixture of methanol and acetonitrile as the mobile phase at flow rate of 0.5 mL/min and detection was done at 222 nm. The retention time of the drug was 1.63. The results obtained with the proposed methods are in good agreement with labeled amounts, when marketed pharmaceutical preparations are analyzed. The recovery in the present method is in the range of 99.24 - 99.56. Results obtained are found to be reproducible.