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Quantitative Estimation of Bumadizone and Phenylbutazone in Bulk and Pharmaceutical Dosage Form Using Two Spectroscopic Methods

Ea. Taha

Two simple, accurate, sensitive and economic analytical techniques were carried out for quantitative estimation of Bumadizone and Phenylbutazone either in bulk or pharmaceutical preparation. The first method is derivative spectrophotometry which carried out for their quantification measurement of the two drugs in their binary mixtures, the zero crossing of the wavelengths detected, and calibration curves were depicting the linearity. The wave length were found to be 243nm and 256nm for, Bumadizone and Phenylbutazone respectively. Both of peaks were symmetrical in nature and low value of tailing when plates were scanned. Adequate separation of the two drugs enabled the development of a selective and specific method of analysis. The second method was carried out using Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopic, the first derivative of the amplitudes of bumadizone and phenylbutazone, were measured at 1179.97 cm-1 and 1092.01 cm-1 for bumadizone and phenylbutazone, respectively, and the extract was directly measured in liquid phase mode using a specific cell Znse. Concluded that these methods can be used to quantify the pure and formulations containing Bumadizone and Phenylbutazone. Moreover, validation of these methods was carried out following International Conference of Harmonisation guidelines.