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Prenylated Chalcones: A Review of Antimicrobial Properties and Structural Diversity

Rajni Godara*, Parshant Kaushik, Virendra Singh Rana, Sameer Ranjan Misra, Kailash Pati Tripathi, Rakesh Kumar, Riya Kundu and Najam Akthar Shakil

Chalcones, precursors to open chain flavonoids and isoflavonoids, are commonly found in edible plants. The remarkable bioactivity displayed by chalcones and their prenylated derivatives has garnered significant attention due to the presence of active α,β-unsaturated keto groups. The vast structural diversity of chalcones has paved the way for the development of newer agrochemicals. Frequently, naturally occurring chalcones contain prenyl units that are critical for their biological properties. This review focuses on prenylated chalcones, both naturally occurring and newly synthesized, that exhibit significant antimicrobial properties.