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Pharmacological evidences for the anti-alzheimer potentials of Sesbania grandiflora Linn. in mice

Hanumanthachar Joshi, S.V.Soumya, Jyoti Bala Chauhan

AlzheimerÂ’s disease(AD) is characterized as a progressive neurode generative disorder and considered as prominent cause of senile dementia in the elderly. It has become recognised as a major cause of morbidity and mortality in the ageing population worldwide. The neuropathologic hallmarks ofAD are neuritic plaques and neurofibrillary tangles. The present study was undertaken to investigate the anti-alzheimerÂ’s potential of Sesbania grandiflora Linn. (SG) in mice. Ethanolic extract of leaves and aqueous extract of flowers of SG(50 and 100mg/ kg, p.o.)were administered for 5 successive d to both young and aged mice. Exteroceptive behavioral model employed to evaluate learning and memorywere elevated plusmaze and interoceptive behavioralmodelwere scopolamine (0.4mg/kg, i.p.) and natural ageing induced amnesia. Piracetam (200mg/kg, i.p.) was used as a standard nootropic agent. SG(50 and 100mg/kg, i.p.) significantly decreased whole brain acetyl cholinesterase activity, lowered serum cholesterol levels and reversed the amnesia induced by both scopolamine (0.4mg/kg, i.p.) and natural aging. Hence, SG can be a suitable memory restoring agent in the management of cognitive dysfunctions such as dementia and AD.