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Paraoxonase 1 in women with Polycystic Ovary Syndrome

Doddappa Bannigida, Shivananda Nayak*

Background: Oxidative stress (OS) plays a crucial role in the development of insulin resistance in women with polycystic ovary syndrome (PCOS). Serum paraoxonase 1 (PON1) level is an antioxidant associated with HDL complex. Diminished activity of PON1 enzyme and increased levels of malondialdehyde (MDA) has been reported in variety of diseases involving oxidative stress. Objective: To compare the serum levels of PON1, MDA and lipid parameters in obese and normal women with PCOS with their respective controls. Materials and methods: Case-control study was carried out at the Biochemistry Department, Koppal Institute of Medical Sciences, Koppal, India from July 2015 to March 2018. It included 100 women with PCOS (50- obese and 50 normal) and 100 control subjects (50- obese and 50 normal), aged 18 to 40 years. Fasting lipid profile, malonaldehyde (MDA) and PON 1 were estimated. Results: There was no dyslipidemia in women with PCOS. Serum levels of PON1 were significantly decreased and MDA levels were increased in women with PCOS irrespective of BMI compared to their respective controls with a p value of <0.001, suggesting a significant inverse correlation between PON1 activity and MDA concentrations in women with PCOS irrespective of BMI. Conclusions: Women with PCOS have increased oxidative stress irrespective of BMI indicated by decreased serum PON1 and increased levels of serum MDA. However, there was no dyslipidemia.