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New RP-HPLC method for the estimation of ziprasidone hydrochloride in pharmaceutical dosage forms

K.Srinivasa Rao, K.Srinivas, S.Satyanarayana Raju

A simple reverse phase HPLCmethod was developed for the determination of Ziprasidone Hydrochloride present in pharmaceutical dosage forms. A Hypersil ODS C18, 4.6mm 250 mm, 5mcolumn, with the mobile phase acetonitrile: ammonium acetate buffer (pH-5) (70:30 %v/v) was used. The flow rate was 1.2 ml/min and effluent was monitored at 225 nm. Abacavir sulfate is used as internal standard. The retention times were 4.88 min and 2.43 min for ziprasidone hydrochloride and abacavir sulfate respectively. The linearity range was found to be 0.5-200g/ml for ziprasidone hydrochloride. The proposed method was also validated.