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Neurotoxicity of Acetamiprid in Male Albino Rats and the Opposite Effect of Quercetin

Gasmi S, Rouabhi R, Kebieche M, Salmi A, Boussekine S, Toualbia N, Taib C, Henine S, Bouteraa Z and Djabri B

The main aim of this work is to study the opposite effects of Quercetin against neurotoxicity induced by an environmental pollutant in albino rats; after administration of Acetamiprid at (3.14 mg/kg/day) of body weight orally during 90 days we have found that Acetamiprid has caused a neurotoxic effect (a decrease in relative brain weight, a decrease in lipids (0.54 ± 0.01), an increase of carbohydrates (1.43 ± 0.05) and total proteins (6.97 ± 0.02) of the brain), Acetamiprid has also an overall pro-oxidant effect, this is revealed by the significant reduction in the level of reduced Glutathione (5.01 ± 0.31), and activity of Glutathione peroxidase (0.042 ± 0.002) and catalase (1.26 ± 0.04) in the brain and on the other hand, we recorded an increase in enzyme activity of glutathione s‐transferase (0.018 ± 0.002), the rate of MDA (0.08 ± 0.009) and Adversely affect the behavior and lifestyle. Our results have showed that supplementation of the Quercetin at (10 mg/kg of body weight/day) by oral way in rats treated with Acetamiprid, improved some biochemical parameters, and declined other adverse effects of Acetamiprid, and that the Quercetin appears to be a simple and effective antioxidant to reduce the imbalance between the formation of free radicals and antioxidant systems of the body and consequently reduced the intensity of oxidative stress induced by Acetamiprid.