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Liver function tests in diabetic and non-diabetic patients in dhaka city of bangladeshi population

Md.Jahangir Alam, Most.Nur-E-Taj Mokarrama Mukti, Md.Mominul Hoque, Md.Rezaul Karim, Md.Saiful Islam, Sunil C.Mallik, Subhagata Choudhury

These studies evaluated the liver function test in diabetic and non diabetic patients. The measuring parameters were fasting blood sugar, total bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total protein, albumin and globulin. The study was carried out in BIRDEM hospital (Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders). This study investigated a total of 459 diabetic patients and 193 non diabetic individuals to compare the level of liver function tests between diabetic and non-diabetic patients. Their ages ranged between 30 and 60 years. The biochemical parameters did not differ significantly between non-diabetic male and female patients. In this study, mean values ofALT (p<0.041),ALP (p<0.001) and total bilirubin (p<0.001) were significantly higher in diabetic patients than in the non diabetic patients. Total protein (p<0.001) and albumin (p<0.007) concentrations in patients were lower compared to non diabetic patients. The mean of serumfasting blood sugar in patients revealed significant difference (P<0.001) in comparison to the non diabetic patients. Overall BMI of diabetic patients were high. Although the differences were statistically significant, the means of ALT, AST, andALPwere falling within the abnormal range.Moreover, 27.66% (127) patients had increased one or more liver enzymes in diabetic patients.