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Instrumental Analysis and the Molecular Docking Study for the Synthesized Indole Derivatives

Navneet Singh and Rajat Malik

In the present work, the formation of 2-phenyl indole, 2 was carried out by the Fischer Indole Synthesis method through AcetoPhenyl hydrazine (1) and by cyclaization with Polyphosheric acid (PPA). 2-Phenyl Indole (2) was also synthesized by alternate method from direct Acetophenone through conc. H2SO4. The derivative 2-phenyl-1H-Indole-3-carbaldehyde (3a) was synthesized from Compd. (2) by the method of Vilsmeier reaction using Phosphorous oxy chloride in DMF. Phenyl (2-phenyl-1H-indol-3-yl) methanone (3b) and 1-(2-phenyl-1H-indol-3-yl) ethan-1-one (3c) was prepared by the Friedal Craft reaction method using benzoyl chloride and acetyl chloride respectively along with aluminum chloride and DCM. The synthesized derivatives (1), (2) and (3a-c) were screened for instrumental analysis and molecular docking studies.