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Identification of the Suitable Model Organism for Human Caspases Study Using Bioinformatics Approach

Jinny Tomar and Neeru Sharma

Caspases are critical for a cell functioning. To understand the functioning of human caspases different model organisms could be considered. Our study suggests that human executioner caspases, initiator caspases and inflammatory caspases shows different level of association with the model organisms under study. This study suggests that for human caspases related studies either Pan troglodytes or Felis catus should be considered based on the extent of sequence similarity. This clearly indicates that we should rethink while performing experiments on Mus musculus, as it may not show the same level of association, thereby may lead to decrease in the efficacy of drug designed for humans and tested on mouse.