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Gas chromatographic determination of celecoxib from tablet

U.M.Talekar, S.J.Kokate, H.R.Aher, S.R.Kuchekar

A gas chromatographic technique was developed for the quantitative determination of non-steroidal anti-inflammatory drug (NSAID) celecoxib in its solid dosage form. p-Nitro aniline is used as internal standard. In proposedmethodHP-5 capillary column (15meter length, 0.53mmi.d., 1.5 u film thickness), nitrogen as carrier gas with flow rate 12 psi., oven temperature programming with split type injector was used and detector is a flame ionization detector.The retention time of celecoxib and p-Nitro aniline is 4.6 min and 1.5 min respectively. Linearity is in the range of 2 mg/ml to 7 mg/ml (r2=0.9999). The percentage recovery is 99.8%. The proposedmethod is useful for quantitative estimation of celecoxib in its tablet form. It is simple, fast, accurate and precise.