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Formulation and Evaluation of Controlled Release Cefixime-CMC Biopolymer Using Ion Cross Linking Technique

Yousif K. Abdul Amir, Mohammed A. K. Alsouz and Ali J. Salim

The main concept in the design controlled-release drug delivery systems is the kinetics of drug release, rather than the kinetics of drug absorption controls the availability of the drug. The controlled release microspheres of cefixime using sodium carboxy methyl cellulose and FeCl3/FeCl2 as cross linking agent. The micro-beads were prepared using ionotropic gelatin technique. The prepared micro-beads were evaluated by in vitro drug release and Fourier transform infra red spectroscopy (FTIR). The evaluation of drug controlled release was performed at different pH (1.2 & 7.2) and different temperatures (27, 37, 45oC). The results were revealed that the drug releasing was increased with rising of temperatures and faster at pH equal to 7.2. FTIR Spectroscopy was revealed that there is no chemical interaction between the drug and excipients. Korsmeyer‐Peppas and Higuchi, zero and first order kinetic models was studied and discussed. Correlation coefficient (r2) values of the kinetic release process suggest that the drug release obey Korsmeyer‐Peppas kinetic model.