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Evaluation of antipyretic activity of Azima tetracantha Lam. in rats

Maruthi T.Ekbote, C.K.Ramesh, Riaz Mahmood, B.S.Thippeswamy, Veeresh Verapur

Azima tetracantha Lam. belongs to Salvodoraceae and known as Kundali in Ayurvedic medicine. The chloroform and alcoholic extracts of Azima tetracantha Lam leaves at doses of 250 and 500mg/kg, p. o. were tested against brewersÂ’s yeast induced pyrexia in rats to assess antipyretic activity. The pyrexia in rats was reduced significantly compared to that of respective control. The effects of these extracts are compared to standard drug Paracetamol. The results obtained from the present investigation indicate that plant extracts possess antipyretic activity. The phytochemical screening of the extracts revealed the presence of secondary metabolites like alkaloids, flavonoids, tannins, triterpenoids, steroids, saponins etc.,