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Evaluation of Anticonvulsant Activity of Novel Indole Derivatives

Sarang D. Kulkarni, Anil N. Tankar, K. B. Patwardhan, R. B. Govindwar, K. Anandarajgopal and Ravi N. Tiwari

Epilepsy affects 0.5-1% of the population. Often, there is no recognizable cause, although it may develop after brain damage, such as trauma, infection or tumor growth or other kinds of neurological disease. Epilepsy is a very common neurological disorder, characterized by seizures, which take various forms and results from episodic neuronal discharges, the form of the seizure depending on the part of the brain affected. Current antiepileptic drugs are effective in controlling seizures in about 70% of patients, but their use is often limited by side effects. Novel mannich bases of indole were synthesized by using a series of aldehydes and secondary amines in presence of ethanol with magnetic stirring for 4-6 hours in cold condition. The structures of these compounds were established on the basis of spectral data. The synthesized compounds were evaluated for anticonvulsant activity by maximum electroshock induced convulsions method on Wister albino mice of either sex (25-30 gm). Phenytoin was used as standard drug. Some of these synthesized compounds shown significant anticonvulsant activity.