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Electrochemical Study on complexation of the antitumor 1,3-dihydroxy thioxanthone with aluminum(III) ion in a mixed solution

Abdollah Yari, Fatemeh Norouzi

This work presents the results of investigating the complexation of 1,3- dihydroxy-9H-thioxanthen-9-one (DTX)withAl(III) by electrochemical techniques, cyclic voltammetry (CV), square wave voltammetry (SWV), and differential pulse voltammetry (DPV). To determine the nature and stoichiometry of the complexes, tetrabutylammonium chloride (n-Bu)4NCl.H2O (TBAC) 0.01 M was found to be a suitable supporting electrolyte in a 1:1 ratio mixed acetonitrile:water solution as solvent. The results showed that reaction of the formed 1:1 and 1:2 (metal:ligand) complexes ofAl(ÉÉÉ) are electrochemically irreversible. The modified DeFord-HumeÂ’s method was used to evaluate the stability constants and the composition of the formed complexes. The overall stability constants 1 and 2 values for the abovementioned complexeswere of 4.17 × 101 and 1.86 × 104, respectively.