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Efficient One-Pot Three-Component Mannich Reaction for the Synthesis of Barbituric Acid

S Ravichandran and C Murugesan

An environmentally friendly organic synthesis of novel Barbituric acid using SnCl2.2H2O under microwave irradiation herein described. The reaction time is very short with reasonable yield enhancement. Further the role of SnCl2.2H2O is studied in the reaction under microwave irradiation and concluded that microwave assisted SnCl2.2H2O catalyzed reaction is the best in terms of catalysis as well as reaction yield improvement.