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Effect of Some Cations as Counter Ions on Ulcer Healing Activity of Glycyrrhetinic Acid on Male Albino Rats

Sharad Visht and G. T. Kulkarni

Ulcer is a disease, which is treated with various drug salts as medicines. The present study was performed to find the contribution of counter ions on ulcer healing activity. The albino rats were selected and divided into six groups comprising minimum of 6 rats and all groups received 0.05 mL of 30% acetic acid (necrotizing agent) into the gastric wall to induce peptic ulcer. All groups received respective treatments for seven consecutive days by oral route except control group. On 8th day all rats were sacrificed and lesions measured. The prepared salts of glycyrrhetinic acid with different counter cation showed the variation in pH. The ulcer healing was maximum in case of glycyrrhetinic acid ammonium and minimum in case of glycyrrhetinic acid calcium, which may be due to increased protease activity, which is more at less acidic/alkaline pH so it may be a reason for interfering in ulcer healing. The one way analysis of variance showed p value < 0.0001, considered extremely significant. Histological studies revealed that ulcer control group exhibited severe damage of gastric mucosa as compared to treatment groups.