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E.coli quorum sensing: Appraisal towards curtailing pathogenesis

S.Adline Princy, V.Praveen Krishna, Vinothkannan Ravichandiran, Surasikha Rangarajan

Lower organisms need to communicate with each other to performvarious activities needed for their survival. Microbes have evolved in an astounding manner to develop tailor-made systems to enhance their chances of existence in harsh environmental conditions. They carry out these mechanisms by synchronizing their actions through cell-to-cell communications. These intra-cellular communications bring about a molecular chain of events to spread infection through biofilm formation and virulence. This review shines a spotlight on the entire Escherichia coli quorumsensing network, especiallywith regard to SdiA.As is apparent from earlier studies, SdiA acts as a global regulator for E. coli quorum sensing. We propose that by antagonizing SdiA, virulence and biofilm formation can be contained, thus suppressing pathogenesis of E. coli. As an extension, other Gram-negative microorganisms that have analogous circuits to E. coli can also be constrained.