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Docking Study of some N-[4-(4-Arylidene)-2-(4-substituted-phenyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-benzenesulfonamide Derivatives against Glucosamine-6-phosphate Synthase

Jaafar Sataar Shia, Redha I. Hussain Al-Bayati, Ahmed Mutanabbi Abdula and Kawkab Y. Saour

Docking study of N-[4-(4-arylidene)-2-(4-substituted-phenyl)-5-oxo-4,5-dihydro-imidazol-1-yl]- benzenesulfonamide derivatives (1-5) against glucosamine-6-phosphate synthase, the target enzyme for the antimicrobial agents was achieved to explore and explain the affinity of discovered hits within the amino acid residues of the enzyme. The previously synthesized derivatives (1-5) exhibited moderate to potent activity against several bacterial species as well as Candida albicans, the common fungi species. In order to understand the interaction types of synthesized hits within the binding pocket of target enzyme, Autodock 4.2, the effective tools for the docking study of small molecules within the active side of enzyme was used.