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Dimethyl cyanamide as a promoter for the one-pot, three-component synthesis of a novel series of 1,3-oxazines using tetrachlorosilane/zinc chloride as a heterogeneous catalyst

TamerK.Khatab, EbrahimAbdel-Galil, EzzatM.Kandeel

The 1,4-dipoles generated from two moles of aromatic ketones have been shown to react efficiently with dimethyl cyanamide via a one-pot [4þ+2] annulation at ambient temperature resulting in the diversity oriented synthesis of a novel series of 1,3-oxazine derivatives through MCR protocol in the presence of tetrachlorosilane - zinc chloride as a heterogeneous promoter.