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Dietary D-psicose enhances gene expression of GLUT2 and glucokinase in rat liver

Tatsuhiro Matsuo

The effect of long-termintake of D-psicose on the gene expressions related to glucose utilizationwas studied. Expressions ofmRNAs for GLUT2 and glucokinase in the liver were markedly enhanced by the intake of dietary Dpsicose. Serum glucose concentration was lower and liver glycogen content was higher in rats fed D-psicose diet than in rats fed control diet. These results suggest that the long-term feeding of D-psicose enhances the glucose transport action and phosphorylation followed by the glycogen synthesis in hepatocyte, which prevents the elevation of the blood glucose level.