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Development and validation of spectrofluorimetric method for the estimation of Flupirtine maleate in bulk drug and pharmaceutical dosage form

Umang Shah, Mansukh Kavad, Manan Raval

Spectrofluorimetric analysis for the quantification of Flupirtine maleate belongs to centrally acting non-opioid analgesic in pure and pharmaceutical dosage form is described. The calibration curves were found linear between fluorescence intensity and drug concentration in the range of 50- 300 ng/mlwith coefficients of determination above 0.9992 for all the analytes. Fluorescence wasmonitored at 388 nmemission wavelength while excited at 320 nm. Themethod recoverieswere higher than 99%. The%RSD value of intra- and interday variation coefficients were observed less than 2%. The limits of detection (LOD) and limit of quantification (LOQ) were found in the range of 6.216 ng/ml and 18.839 ng/ml, respectively.Thus, themethod will be applied successfully to the determination of the cited drugs in pure and pharmaceutical dosage with good accuracy and precision. These methods are simple, accurate and rapid; those require no preliminary separation and therefore can be used for routine analysis of Flupirtine maleate in quality control laboratories. 2013 Trade Science Inc. - INDIA.