Абстрактный

Cyclopolymerization of Diallylamine and its Condensation with Carboxylic Drugs

Khudheyer Jawad Kadem

In this study, the polydiallylamine (P1) was prepared by free radical cyclopolymerization then the three new drug carriers cyclopolymers (P2-P4) were prepared according to substitution polymer P1 to its amine of prepared diallylamine polymer P1 to its corresponding N-drug through amide attachments such as N-Ibuprofine, ciprofloxacin and mefenamic acyl chloride, which formed amide bonds. This can be hydrolysed in different pH values at 37oC, as controlled drug release to obtain a sustained drug release. This can lead to improve their activities as a therapeutic material and to prevent any side effect of the drugs. The cyclopolymers (P1-P4) were characterized by Fourier Trans Infrared (FTIR), Proton Nuclear magnetic resonance 1H-NMR and UV-Vis spectroscopies. Additionally, intrinsic viscosity was measured and all physical properties were measured.