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Correlation between glomerular filtration rate produced from the modified gates (in vivo method) and the modification of diet in renal disease (in vitro method) for patients with renal diseases

Osiris W.Guirguis, Rania M.Abdel Halim, Adel M.K.Meselhy

Rapid and accurate estimation of the glomerular filtration rate (GFR) is required in the assessment of patients with chronic kidney disease and in order to provide information regarding to the functional status of the kidney. In the present study, the GFR is determined by gamma camera uptake method modified Gates (in vivo method) andModification of Diet in Renal Disease method (MDRD) (in vitro method). 99mTc-DTPA renography is performed by GatesÂ’ method (in vivo) to obtain GFR and correlated byGFR that predicted byModification of Diet in Renal Disease equation (in vitro) after adjustment different parameters on the evaluation of the glomerular filtration rate of 153 patients with a wide range of renal function, such as: radioactive 99mTc-DTPA dose that administrated to patient, time of counting pre-injected syringe, post-injected syringe and the distance between syringe and detector of gamma camera. The obtained results show that, comparison of GFR that calculated by GatesÂ’ method with that of GFR estimated byMDRD equation in the 153 patients resulted in a significant and good correlation when using the following parameters: administered radioactive dose ranged from 10 to 15 mCi of 99mTc-DTPA with time of 10 seconds for pre-syringe counts, time of 30 seconds for post-syringe counting and at distance 30 cm from the detector of gamma camera. In addition, the correlation is better in case of chronic renal failure and reduced renal function than in case of healthy group.