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Combinatorial Drug Design- formulation of the Era

Subin Mary Zachariah, K. Leena Pappachen, K. N. Fasmi, Stimson Jose and Arathi Vimal

The field of medicinal chemistry and drug design is in a state of development and is at present undergoing major restructuring. The molecular biological revolution and the progressing mapping of the human genome have created a new biochemical and biostructural great order. These developments have provided new challenges and opportunities for drug research and drug design. The aim of this review is to know more about the newly formulated drugs with the use of computer aided designed drugs and molecular modeling. One can site the advances in the understanding in the reaction mechanism, conformational analysis, host - guest interactions, quantum mechanics and so on. The major objective of the medicinal chemist is in designing molecules interacting with the degenerating process in the diseased organisms.