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CNS Activity of New Indole Derivatives

K. S. Nataraj, J. Venkateshwara Rao and K. N. Jayaveera

Twenty one new 2-{(benzalamino-4-hydroxybenzyl) (1, 3, 4)-oxadiazino[6, 5-b]} indole derivatives have been synthesized by condensing 2-amino-4-[(1, 3, 4)oxadiazino[6,5-b]indole-3-yl]- phenol with various aromatic aldehydes. The intermediates, on the other hand, have been synthesized by the cyclization of 3-amino-4-hydroxy-benzoic acid (2-oxo-1, 2-dihydro-indol-3-ylidene)-hydrazide in presence of concentrated H2SO4. The title compounds have been purified and characterized by their analytical and spectral data. They have screened for their gross behavioral studies, effects on locomotor activity and on pentobarbitone sodium induced sleeping time. All the test compounds exhibited reduction in locomotor activity, compound (9) exhibited more effect among all the test compounds and potentiation of pentobarbitone sodium induced sleeping time ranges from 166.66 per cent to 276.66 per cent. The compound (15) showed more activity with a potentiation of 276.60 per cent in experimental animals.