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Chemistry and pharmacology of benzodioxanes

Bahar Ahmed*, Habibullah, Shamshir Khan

Benzodioxane represents a series of synthetic and natural compounds of considerable medicinal importance. Compounds containing dioxane ring systems exhibited different biological activities such as antihepatotoxic, -adrenergic blocking agent, neuroleptic, anti-inflammatory, hypolipidemic and D2 antagonist/5-HT1A partial agonist activity. The literature concerning chemistry of benzodioxanes chemistry is scattered and has not been reviewed so far. The present article covers the various methods of preparing 1, 3-and 1, 4-benzodioxane ring system, different chemical reactions, and their different biological activities.