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Biological Evaluation and Optical Activity of Some 1-Arylisothiocarbamides

P. T. Agrawal

Several S-hepta-O-benzoyl maltosyl-1-arylisothiocarbamides have been synthesized by the interaction of hepta-O-benzoyl maltosyl bromide and various aryl thiocarbamides. The identities of these newly synthesized compounds have been established on the basis of usual chemical transformation and IR, 1H NMR and Mass spectral studies. Carbohydrate derivatives bearing N- and S-linked functionalities at anomeric position are known for their various biological activities and in medicinal chemistry. This class of compounds has several applications such as antifungal, antitumor, anticancer, antiviral and antimalerial activity. In view of applications in industry and also in medicinal chemistry it appeared interesting to carry out synthesis for some novel thiomaltosides and to perform their biological evaluation.