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Antigenotoxic effect of EGCG against androgenic steroids stanozolol and trenbolone

Tanveer Beg, Yasir Hasan Siddique, Gulshan Ara, Jyoti Gupta, Mohammad Afzal

A catechin, EGCG, was studied for its antigenotoxic effect on CAs and SCEs induced in human lymphocytes by androgenic steroids, Stanozolol and Trenbolone. The steroids induced CAs and SCEs at 40 and 60Mand EGCGwas used at 20 and 30 µM along with both steroids separately. EGCG was found to reduce significantly the genotoxicity caused by both steroids, with and without metabolic activation, but the antigenotoxic potential of EGCG was higher in the presence of metabolic activation system.