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Antidiabetic, antihyperlipidemic and histopathological analysis of Cleome droserifolia methanolic extract on alloxan induced diabetic rats

M.A.Nagy

Objective: To investigate antidiabetic, hypolipidemic histopathological analysis of Cleome droserifolia methanolic extract (CDE) extract in alloxan induced diabetic rat by administering oral dose (0.31 g /kg body weight / day). Methods: Optimal cutoff level of each of the four plasma glucose values of oral glucose tolerance test in alloxan diabetic rat was done. Other parameters as liver profile, renal profile and total lipid levels were determined in normal and alloxan induced diabetic rats after oral administration of the extract for 30 days. Histopathological changes in diabetic rat organs (pancreas, liver and kidney were also observed after extract treatment. Results: Daily oral administrationCDE (0.31 g /kg bodyweight) and glimebride (10 microg/g body wt) showed beneficial effects on blood glucose level (P<0.001) as well as improving kidney, liver functions and hyperlipedemia due to diabetes. The extract treatment also showed enhanced seruminsulin level and body weight of diabetic rats as compared to diabetic control group. Furthermore, the extract has a favorable effect on the histopathological changes of the pancreas, liver and kidney in alloxan induced diabetes. Conclusion: Cleome droserifolia posses antidiabetic property as well as improve bodyweight, liver profile, renal profile and total lipid levels. CDE has also favorable effect to inhibit the histopathological changes of the pancreas and kidney in alloxan induced diabetes.